The Dominican friars are present in the lands of Andalusia, since the year 1236, when the city of Cordoba was reconquered by King Ferdinand III the saint. After the city was taken, the monarch donated the Royal Convent of St. Paul. The presence of friars preachers between the entourage of the Holy King is documented, and by the hand of his campaigns of reconquest, the presence of the new mendicant orders is given in the lands of the southern crown of Castile.

The Dominican convents in Andalusia, like the one that occupies the Hotel convento de Santo Domingo, became centers of evangelization and foci of Christian Culture: General Studies, Studies of languages (Arabic and Hebrew) and universities were entrusted to the order.
In the year 1630, the Dominican Order established a hospice in Cadiz and five years later managed to establish its convent. It was not until 1643, when the corresponding permits were obtained for the edification of the convent, as it is known today,. The work began two years later and that of the church in 1652, with the alarifs or masters of Works Antón Martín Calafate and Bartolomé Ruiz. It was completed by Luis de Lojo in 1666.
Over the years, the convent came to have a great prestige in the field of teaching, since from the end of the 17th century hosted a house of studies, compiling a large library.